Differences in Response of Large-Vessel Endothelium and Capillary Endothelium Following Intracarotid Mannitol

Autor:	J. C. Godersky, N. F. Kassell, T. Sasaki
Rok vydání:	1985
Předmět:	Endothelium Potential risk business.industry Central nervous system Large vessel Pharmacology Capillary Endothelium medicine.anatomical_structure Drug delivery cardiovascular system medicine Antineoplastic Drugs Mannitol business medicine.drug
Zdroj:	Brain Edema ISBN: 9783642706981
DOI:	10.1007/978-3-642-70696-7_19
Popis:	Transient osmotic disruption of the BBB has been advocated by Neuwelt et al. [3] as a vehicle for increased drug delivery into the brain for treatment of central nervous system (CNS) malignancies. However, a number of drugs administered in this manner have been shown to be neurotoxic [4]. This study was designed to investigate the effects of hyperosmolar solutions on the endothelium of the major extracranial and intracranial arteries and to contrast this with the effects on the cerebral capillary endothelium. A potential risk of injury to the vessels exists if antineoplastic drugs are able to penetrate the vessel wall following the administration of mannitol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b70b2cead1845a01c68d8e7aaa04cca7 https://doi.org/10.1007/978-3-642-70696-7_19 Zobrazit plný text záznamu