Nitric oxide and nitric oxide synthase as early predictors of the clinical outcome of chronic bladder lesions including malignancy

Autor:	Olfat Hammam, Wafaa Mansour, Ahmad G. Elbaz, Hanan El-Baz, M. Morsy, A. Abdel-Hakiem
Rok vydání:	2007
Předmět:	medicine.medical_specialty Predictive marker Bladder cancer biology business.industry Urinary system Public Health Environmental and Occupational Health Urology Cancer Chronic Cystitis medicine.disease Malignancy Nitric oxide synthase Infectious Diseases medicine biology.protein Urothelium business
Zdroj:	Travel Medicine and Infectious Disease. 5:406-407
ISSN:	1477-8939
Popis:	Background Bladder cancer is the most prevalent cancer in Egypt and in most African countries. Two distinct types of bladder cancer exist in Egypt, namely the bilharzial and non-bilharzial types. Nitric oxide (NO) exerts several functions in benign and malignant human tissues. Many studies have proved significantly higher urinary NO levels, as well as presence of inducible nitric oxide synthase (iNOS) in bladder tumors. Because tissue iNOS is responsible for the production of urinary and serum NO, it is possible that urine from bladder cancer patients includes high levels of NO. Aim of the work To study serum and urinary levels of NO as well as iNOS expression in bladder tissue of patients with different chronic schistosomal and non-schistosomal bladder lesions including malignancy to determine the possibility of using them as biological markers for early diagnosis and prediction of the clinical out come of bladder tumors. Patients and methods Sixty five patients; 40 with malignancy and 25 with chronic cystitis, were included in the study. Seventeen individuals with apparently normal urothelium served as controls. NO was assayed in urine and serum using the modified Griss reaction technique. Expression of iNOS in bladder tissue was determined by indirect immunohistochemical techniques. Results All controls were negative for NO in both serum and urine. The rate of positivity of NO in sera of the malignant group was significantly higher than in the chronic cystitis group ( p p p Conclusion Urinary and serum NO levels as well as iNOS expression in bladder tissue could be used as tumor markers for diagnosis of bladder cancer. Urinary NO could be also used as an early non-invasive predictive marker for the tumor behavior and prognosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b6fa9c505a2d8d872566f05a735ca978 https://doi.org/10.1016/j.tmaid.2007.09.024 Zobrazit plný text záznamu Full Text from ScienceDirect