Quality and Quantity in Kidney Cancer Surgery
| Autor: | Michael A. Liss, Ian W. Gibson, Sacha Oomah, Vivian Lu, Thomas McGregor, Deepak Pruthi, Corey Knickle, Iain D.C. Kirkpatrick, Tommy Ting |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Kidney
medicine.medical_specialty business.industry medicine.medical_treatment Urology Renal function General Medicine Arteriosclerosis medicine.disease Preoperative care Nephrectomy 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Glomerulopathy 030220 oncology & carcinogenesis Diabetes mellitus medicine business Kidney cancer 030215 immunology |
| Zdroj: | American Journal of Clinical Pathology. 151:108-115 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/aqy107 |
| Popis: | Objectives To model renal function 2 years following radical nephrectomy with quantitative analyses using clinical, histopathologic, and renal composite cortical volumes (CCV). Methods This retrospective study involved an assessment of the nonneoplastic kidney tissue by three blinded nephropathologists using modified Banff 1997 criteria for renal allograft pathology. Volumetric image acquisition was obtained by three independent radiologists using preoperative imaging. A 2-year estimated glomerular filtration (eGFR) calculator was created. Results Among the 126 patients, median age was 60 years; median CCV, 398.1 cm3; preoperative eGFR, 77 mL/min/1.73 m2; and 2-year postoperative eGFR, 54 mL/min/1.73 m2. Of the subjects, 64% had hypertension, 26% diabetes, and 37% were smokers. Increasing age, glomerulopathy/sclerosis, tubulointerstitial scarring, and arteriosclerosis were statistically significantly and adversely associated with eGFR. Conversely, increasing CCV was associated with a higher eGFR. Conclusions Quantitative analysis of the nephrectomized kidney in conjunction with patient age can accurately predict renal function at 2 years. |
| Databáze: | OpenAIRE |
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