Studies of skeletal cadmium assay and toxicity
| Autor: | Robert E. Jervis, S. S. Krishnan, R. Dowlati, A. J. W. Hitchman, S. M. W. Lui, Joan E. Harrison, B. Krishnan |
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| Rok vydání: | 1988 |
| Předmět: |
Detection limit
Cadmium Kidney Chromatography Osteoid Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health chemistry.chemical_element Pollution Analytical Chemistry law.invention medicine.anatomical_structure Nuclear Energy and Engineering chemistry Dry weight law Environmental chemistry Toxicity medicine Radiology Nuclear Medicine and imaging Inductively coupled plasma Atomic absorption spectroscopy Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry Articles. 124:79-84 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/bf02035507 |
| Popis: | Flameless Atomic Absorption Spectrophotometry was found to be a sensitive (2·10−12 g detection limit), accurate but destructive method for cadmium assay in bone biopsy samples (about 30 mg dry weight). The inductively coupled plasma emission technique was poorer in sensitivity (1.2·10−9 g) and is also a destructive method. Activation Analysis is still less sensitive (2·10−8 g detection limit) but a nondestructive one. Cadmium was found to accumulate in bone of rats fed, for 5 weeks, 0, 50, and 100 mg Cd/l in drinking water and the bone concentrations were 0.16, 1.09, and 2.6 mg Cd/kg bone (dry wt). Histological examination of the bones showed that cadmium induced increased osteoid surface in the bone with no evidence of accompanying kidney damage. This suggests a primary effect of cadmium on bone rather than secondary effect due to kidney damage. |
| Databáze: | OpenAIRE |
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