Synthesis, characterization and anticancer evaluation of novel tri-arm star shaped 1,3,5-triazine hydrazones
| Autor: | Shrinath S. Machakanur, Dayananda S. Badiger, S. W. Annie Bligh, Raghavendra P. Bakale, Kalagouda B. Gudasi, Basavaraj R. Patil |
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| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
biology Stereochemistry Organic Chemistry Cyanuric chloride Hydrazone Condensation reaction biology.organism_classification Mass spectrometry Analytical Chemistry Inorganic Chemistry HeLa chemistry.chemical_compound chemistry 1 3 5-Triazine Spectroscopy Benzoic acid Triazine |
| Zdroj: | Journal of Molecular Structure. 1011:121-127 |
| ISSN: | 0022-2860 |
| DOI: | 10.1016/j.molstruc.2011.12.023 |
| Popis: | A series of novel trisubstituted triazine hydrazones [N3C3(single bondOC6H4-p-CHdouble bond; length as m-dashNsingle bondNHsingle bondC(O)single bondC6H4-p-X)3] (X = H, Br, Cl, F, OH, OCH3, CH3, NO2, NH2) were prepared by a three-fold condensation reaction of 2,4,6-tris(4-formylphenoxy)-1,3,5-triazine with p-substituted benzoic acid hydrazides [NH2single bondNHsingle bondC(O)single bondC6H4-p-X] with excellent yields. The structures were confirmed by elemental analysis, FT-IR, 1H, 13C, 2D-HSQC NMR and mass spectrometry (MALDI-TOF). These derivatives bearing hydrolysable hydrazone linkages were evaluated for their invitro antiproliferative activity against the human liver carcinoma cell line (HepG2) and human cervix carcinoma cell line (HeLa). |
| Databáze: | OpenAIRE |
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