| Popis: |
Abnormality of the chromosomal karyotype is one factor causing poor prognosis in patients with lymphoma. Here, in the analysis of the abnormal karyotype of lymphoma patients, the three smallest overlapregions were found, in which MYCT1 was located. MYCT1 was first cloned by our research team as tumor suppressor gene, but studies related to the occurrence and development of lymphoma have not been reported. In this study, we found MYCT1 could inhibit proliferation and promote cell cycle arrest in diffuse large B-cell lymphoma cells. Moreover, we demonstrate that MYCT1 represses RUNX1 transcription by binding MAX. The findings provide clues and a basis for in-depth studies of MYCT1 in the diagnosis, treatment and prognosis of lymphoma. |
