| Autor: |
D. M. Mitrovic, Zoran B. Redzic, S. S. Jovanovic, Ivanka Markovic, Lj. M. Rakic |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Biology and Physiology of the Blood-Brain Barrier ISBN: 9781475794915 |
| DOI: |
10.1007/978-1-4757-9489-2_26 |
| Popis: |
Transport of tiazofurin (2-β-D-ribofuranosyl thiazole-4-carboxamide) across the blood-brain barrier (BBB) was studied using brain vascular perfusion method in the guinea pig. The obtained results demonstrate that brain clearance of 3H tiazofurin significantly differs from zero, suggesting that this molecule penetrates from blood into the brain. The values of tiazofurin brain clearance are very close to the values obtained for neuropeptides and other so called “slow penetrating molecules” (regarding the blood brain barrier). Addition of increasing concentrations of unlabelled tiazofurin to the perfusing medium caused a significant decrease in the uptake of [3H] labelled tiazofurin. Therefore, penetration of tiazofurin from blood into brain seems to be a saturable process. Presence of increasing concentrations of unlabelled adenosine has similar effect as the presence of unlabelled tiazofurin in the perfusing medium. However, it did not cause complete inhibition of tiazofurin brain uptake. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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