elastase inhibitors containing conformationally restricted lactams as P3-P2 dipeptide replacements

Autor:	Stephen Jacober, Philip W. Mui, Jerry W. Skiles, Sorcek Ronald J, Miao Clara K, Alan S. Rosenthal, Mcneil Daniel W
Rok vydání:	1993
Předmět:	Dipeptide Stereochemistry Peptidomimetic Chemistry Organic Chemistry Clinical Biochemistry Elastase Pharmaceutical Science Biochemistry Human Leukocyte Elastase chemistry.chemical_compound Valine Drug Discovery Trifluoromethyl ketone Molecular Medicine sense organs Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 3:773-778
ISSN:	0960-894X
Popis:	The synthesis of potential human leukocyte elastase (HLE) inhibitors containing conformationally restricted lactams as peptidomimetic replacements at P3-P2 and which contain a trifluoromethyl ketone of valine at P1 are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b6e0fee2d6358b5027a3474967bc4662 https://doi.org/10.1016/s0960-894x(01)81273-7 Zobrazit plný text záznamu