The Genesis of Hyponatremia Associated with Marked Overhydration and Water Intoxication

Autor:	James M. Stormont, Christine Waterhouse
Rok vydání:	1961
Předmět:	business.industry Sodium medicine.medical_treatment chemistry.chemical_element Diuresis Urine medicine.disease chemistry Physiology (medical) Anesthesia Medicine Tonicity Water intoxication Mannitol Diuretic Cardiology and Cardiovascular Medicine business Hyponatremia medicine.drug
Zdroj:	Circulation. 24:191-203
ISSN:	1524-4539 0009-7322
DOI:	10.1161/01.cir.24.2.191
Popis:	Prolonged overhydration and hyponatremia have been produced in 10 patients with use of Pitressin Tannate in Oil. Balance studies have shown that in patients who developed moderate hyponatremia, the drop in serum sodium could be explained by water retention. In patients who developed severe water intoxication, the very low levels of serum sodium (100-114 mEq./L.) could not be entirely accounted for by changes in salt and water balance. Certain patients failed to develop severe water intoxication although an equivalent degree of overhydration was achieved. In these subjects, further overhydration was limited by intermittent episodes of low solute diuresis. This diuretic escape from Pitressin effect has been evaluated by measurement of U/P osmolar ratio on 24-hour urine specimens as well as T c H 2 O during hypertonic mannitol infusion. Defects in both aspects of renal concentration were observed, although they were not necessarily coexistent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b6d67bc1f8639a4d1974e80eddb5b1dc https://doi.org/10.1161/01.cir.24.2.191 Zobrazit plný text záznamu