Study of Ca2+, Mn2+ and Cu2+ binding to DNA in solution by means of IR spectroscopy

Autor:	D. N. Grigoriev, S. V. Kornilova, L. E. Kapinos, Valery Andrushchenko, Yu. P. Blagoi, V. L. Galkin, Elene V. Hackl
Rok vydání:	1997
Předmět:	inorganic chemicals Aqueous solution Metal ions in aqueous solution Organic Chemistry Inorganic chemistry Cooperative binding Cooperativity Binding constant Analytical Chemistry Inorganic Chemistry chemistry.chemical_compound chemistry Qualitative inorganic analysis Spectroscopy DNA Macromolecule
Zdroj:	Journal of Molecular Structure. :229-232
ISSN:	0022-2860
DOI:	10.1016/s0022-2860(96)09534-8
Popis:	The interaction of Cu2+, Mn2+ and Ca2+ ions with the DNA macromolecule was studied in aqueous solutions at different metal ion concentrations. All these ions interact with both the bases and the phosphate groups of DNA. Cu2+ ions alter the DNA B-conformation at [Cu2+] > 2 × 10−2M. Metal ions binding to DNA induce DNA compactisation. The highly positive cooperativity of this process was shown. The binding constants and parameters of cooperativity of the metal ions binding to DNA were estimated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b6d599e8ab8f1491735a81cd6fca2661 https://doi.org/10.1016/s0022-2860(96)09534-8 Zobrazit plný text záznamu Full Text from ScienceDirect