Determination of the absolute configuration and identity of chiral carboxylic acids using a Cu(II) complex of pyridine–benzimidazole-based ligand

Autor:	Shintaro Ito, Hiroshi Katagiri, Yoshihiro Ohba, Shuang Zhao
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Circular dichroism Chemistry Stereochemistry Carboxylic acid Organic Chemistry Absolute configuration Enantioselective synthesis Thio Biochemistry chemistry.chemical_compound Drug Discovery Pyridine Chirality (chemistry) Enantiomeric excess
Zdroj:	Tetrahedron Letters. 55:2097-2100
ISSN:	0040-4039
Popis:	We report a new achiral Cu host [Cu(bmb–bpy)(H2O)(OTf)2] (bmb–bpy = 6,6′-bis[((1-methylbenzimidazol-2-yl)thio)methyl]-2,2′-bipyridine) for the enantioselective and chemoselective recognition of chiral carboxylic acids. The binding of chiral carboxylic acids to [Cu(bmb–bpy)(H2O)(OTf)2] produced an exciton-coupled circular dichroism signal; the linear discriminant analysis allowed the assignment of the absolute configuration, enantiomeric excess, and identity of chiral carboxylic acids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b6ce3906035721cd67b17132c83f973e https://doi.org/10.1016/j.tetlet.2014.02.032 Zobrazit plný text záznamu Full Text from ScienceDirect