Synthese und Reaktivität von 3-Oxazolinen

Autor:	Jürgen Jakobxht, Jürgen Martens, Maya Weber
Rok vydání:	1992
Předmět:	chemistry.chemical_classification Oxazolidine Ketone Carboxylic acid Organic Chemistry Medicinal chemistry Aldehyde chemistry.chemical_compound chemistry Acyl chloride Sodium hydroxide Organic chemistry Amine gas treating Reactivity (chemistry) Physical and Theoretical Chemistry
Zdroj:	Liebigs Annalen der Chemie. 1992:1-6
ISSN:	1099-0690 0170-2041
Popis:	Synthesis and Reactivity of 3-Oxazolines. 3-Oxazolines 1 have been prepared from α-hydroxy aldehydes, ammonia, water and a second oxo compound (aldehyde or ketone) in a one-pot reaction. Carboxylic acid chlorides add to the azomethine bond of 1 to yield 3-acyl-4-chlorooxazolidines 2. 4-Hydroxy and 4-alkoxyoxazolidines 3 are obtained from 2 upon treatment with aqueons sodium hydroxide or alkanol/ triethyl amine, respectively. Some oxazolidines 3 are formed with high diastereoseselectivity.
Databáze:	OpenAIRE
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