Health-related quality of life following treatment for extremity soft tissue sarcoma

Autor: Aileen M. Davis, Brian O'Sullivan, Jay S. Wunder, Darin Davidson, Peter Chung, Peter C. Ferguson, Charles Catton, Soha Riad, Anthony M. Griffin, Ronald D. Barr
Rok vydání: 2016
Předmět:
Zdroj: Journal of Surgical Oncology. 114:821-827
ISSN: 0022-4790
DOI: 10.1002/jso.24424
Popis: Background and Objectives The primary objective of this study was to estimate the change in health-related quality of life (HRQL) 1 year following treatment for extremity soft tissue sarcoma (STS), measured by the EQ-5D. Secondary objectives included determining clinical variables associated with HRQL at 1 year, estimating the proportion with a clinically important difference (CID) in HRQL, and evaluating variability within EQ-5D domains. Methods Patients over the age of 16 years, treated for a localized extremity STS, were included. The EQ-5D change score from pre-treatment to 1-year follow-up was determined. The association of clinical variables with EQ-5D scores was estimated using a linear regression model. The proportion of patients with a CID in HRQL score was determined. A vector analysis of the EQ-5D domains was undertaken. Results The mean EQ-5D change score was 0.02. Age, sex, disease status, and initial EQ-5D score were associated with EQ-5D score at 1 year. There was a CID improvement in 32% and a deterioration in 24%. The anxiety and depression domain demonstrated the most change between baseline and 1 year after treatment. Conclusion Most patients maintain a high level of HRQL following treatment for extremity STS. J. Surg. Oncol. 2016;114:821–827. © 2016 2016 Wiley Periodicals, Inc.
Databáze: OpenAIRE
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