Aminolevulinate dehydratase (δ-ALA-D) as marker protein of intoxication with metals and other pro-oxidant situations

Autor:	Cristina W. Nogueira, João Rocha, Solange Cristina Garcia, Fernanda S. Gravina, Rogério de Aquino Saraiva
Rok vydání:	2012
Předmět:	chemistry.chemical_classification biology Chemistry Stereochemistry Porphobilinogen synthase Health Toxicology and Mutagenesis food and beverages Toxicology medicine.disease_cause Pro-oxidant Biomarker Biochemistry Electrophile Lead exposure medicine Thiol biology.protein Oxidative stress
Zdroj:	Toxicology Research. 1:85
ISSN:	2045-4538 2045-452X
DOI:	10.1039/c2tx20014g
Popis:	δ-ALA-D is a metalloenzyme that has 3 vicinal thiol/thiolate groups that coordinate with Zn(II). The proximity between the sulfhydryl groups renders δ-ALA-D extremely sensitive to oxidation by soft electrophiles, such as Pb(II), Hg(II), As(III) and organoseleno and organotellurium compounds. In fact, blood δ-ALA-D is a classical biomarker of lead exposure in humans. The inhibition of δ-ALA-D can increase the concentration of 5-aminolevulinate (δ-ALA), which is a pro-oxidant compound. δ-ALA can generate oxidative stress that can further increase δ-ALA-D inhibition. Recently, data have been obtained indicating that the δ-ALA-D could be a marker of oxidative stress in human pathologies. In summary, considering its high sensitivity to pro-oxidant situations, δ-ALA-D can be considered a universal marker of oxidative stress.
Databáze:	OpenAIRE
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