Photocatalysis in a multi-capillary assembly microreactor: toward up-scaling the synthesis of 2H-indazoles as drug scaffolds
| Autor: | Dong-Pyo Kim, Ki-Won Gyak, Bandaru T. Ramanjaneyulu, Seungwook Jang, Shinde Vidyacharan |
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| Rok vydání: | 2019 |
| Předmět: |
Fluid Flow and Transfer Processes
3d printed Materials science 010405 organic chemistry Capillary action Process Chemistry and Technology Up scaling 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Chemical engineering Chemistry (miscellaneous) Photocatalysis Chemical Engineering (miscellaneous) Fluidics Microreactor |
| Zdroj: | Reaction Chemistry & Engineering. 4:1466-1471 |
| ISSN: | 2058-9883 |
| DOI: | 10.1039/c9re00239a |
| Popis: | Visible-light-promoted direct arylation of 2H-indazoles using phenyldiazonium salt enabled a single-step and fast synthesis ( 65%) in a capillary microreactor, compared to the slow synthesis (18 h) in a flask. Moreover, scalable photocatalysis of a 2H-indazole based liver X-receptor modulator was performed by devising a compact multi-capillary assembly microreactor composed of vertically aligned 10 capillary tubes connected to 3D printed fluidic fixtures. Eventually, the assembly produced the drug on an ∼4 gram scale per hour by a one-flow automated process taken for 2.2 min from synthesis to product separation, which would be a breakthrough approach for pharmaceutical production. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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