Blocking the Nogo-A Signaling Pathway to Promote Regeneration and Plasticity After Spinal Cord Injury and Stroke
| Autor: | Martin E. Schwab, Anna Guzik-Kornacka, Flóra Vajda |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Neurite business.industry Multiple sclerosis Regeneration (biology) Central nervous system medicine.disease 03 medical and health sciences Myelin 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure mental disorders Medicine Signal transduction Amyotrophic lateral sclerosis business Neuroscience Spinal cord injury 030217 neurology & neurosurgery |
| Zdroj: | Translational Neuroscience ISBN: 9781489976529 |
| DOI: | 10.1007/978-1-4899-7654-3_20 |
| Popis: | Myelin of the central nervous system (CNS) exerts an inhibitory effect on growing neurites, leading to restricted axonal regeneration, limited compensatory sprouting, and permanent functional deficit after CNS injury. Nogo-A is a membrane protein enriched in CNS myelin that plays a key role in neurite growth inhibition. In various animal models, application of function-blocking anti-Nogo-A antibodies and of other Nogo-A signaling blocking agents led to enhanced regeneration and compensatory sprouting after spinal cord injury and increased structural reorganization and plasticity after stroke, both associated with improved functional recovery. This chapter discusses recent advances in understanding how Nogo-A and other glia-derived inhibitors limit regeneration and functional recovery after CNS damage. We summarize the current experimental CNS repair strategies and clinical trials that use reagents which neutralize Nogo-A or suppress Nogo signaling, in particular for spinal cord injury and stroke, with some results also in amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). In the future, pharmacological therapies blocking glia-derived neurite growth inhibitors and promoting neuronal intrinsic growth capacities should be combined with well-timed rehabilitative training to optimize recovery of trauma or neurological patients. |
| Databáze: | OpenAIRE |
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