Dystrophin expression in the developing conduction system of the human heart
| Autor: | M. W. M. Markman, G.J.B. van Ommen, S. Viragh, Antoon F.M. Moorman, I. B. Ginjaar |
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| Rok vydání: | 1995 |
| Předmět: |
musculoskeletal diseases
congenital hereditary and neonatal diseases and abnormalities Pathology medicine.medical_specialty Histology Duchenne muscular dystrophy Internal medicine Medicine Myocyte Instrumentation Heart development biology business.industry Cardiac muscle Skeletal muscle musculoskeletal system medicine.disease Medical Laboratory Technology medicine.anatomical_structure Cardiology biology.protein Anatomy Electrical conduction system of the heart business ITGA7 Dystrophin |
| Zdroj: | Microscopy Research and Technique. 30:458-468 |
| ISSN: | 1059-910X |
| DOI: | 10.1002/jemt.1070300603 |
| Popis: | Duchenne muscular dystrophy (DMD) is frequently associated with myocardial involvement. Dystrophin, the DMD protein, is found at the plasmamembrane of striated muscle fibers. Although dystrophin is missing in most or all muscle fibers of DMD patients, cardiac muscle is not as severely affected as skeletal muscle. Therefore it is of great importance to study the expression of dystrophin in normal cardiac muscle. We performed immunohistochemical studies and examined cardiac muscle of fetuses of 8 to 13 weeks of development on dystrophin expression. At these stages dystrophin is observed in the myocytes of the developing ventricular conduction system and in the atrial cardiomyocytes. Dystrophin was absent from the heart of a 12-week-old DMD fetus. |
| Databáze: | OpenAIRE |
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