Molecular and supramolecular characterization of Ni(II)/losartan hydrophobic nanoprecipitate
| Autor: | Jeferson G. Da Silva, Afshin Abrishamkar, Ângelo M. L. Denadai, Antonio S. Mangrich, Amanda A. de França, Lorrayne O. Nascimento, Pedro P. Goulart, Jéssyca M.L. Corrêa |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Organic Chemistry Inorganic chemistry Supramolecular chemistry Nanoparticle Analytical Chemistry Coordination complex Inorganic Chemistry Metal chemistry Rheology visual_art visual_art.visual_art_medium Zeta potential Physical chemistry Titration Solubility Spectroscopy |
| Zdroj: | Journal of Molecular Structure. 1074:224-230 |
| ISSN: | 0022-2860 |
| DOI: | 10.1016/j.molstruc.2014.05.080 |
| Popis: | In this work, a contribution to understanding of the formation of metal(II)/losartan hydrophobic nanoprecipitate is reported. A Ni(II)/Los system was prepared and characterized in solid state and in solution. Solubility studies confirmed the formation of hydrophobic precipitate. Obtained spectroscopic data suggest a sort of coordination between tetrazolic ring as well as OH, and a D 4h geometry around the nickel cation. Thermodynamic studies demonstrated that complexation is a stepwise process, with equal enthalpic and entropic contributions for free energy of complexation. DLS and zeta potential titrations indicate the formation of stable nanoparticles of size and charge dependent on the molar ratio. Finally, rheological studies demonstrate a Bingham plastic behavior for Ni(II)/Los suspension. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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