Effect of extracorporeal granulocytapheresis (G-1) on antigen-induced arthritis in rabbits
| Autor: | Masakazu Adachi, Nobuhito Kashiwagi, Tatuo Ide, Hiromu Shibusawa, Reiji Kasukawa, Tetuzou Agishi, Shinichi Yoshino, Katuya Hiraishi, Shoshirou Asakura |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
biology medicine.diagnostic_test business.industry Arthritis medicine.disease Extracorporeal Flow cytometry Ovalbumin Immune system Antigen induced arthritis Endocrinology Internal medicine Immunology medicine biology.protein Distribution (pharmacology) business Whole blood |
| Zdroj: | Ensho. 14:313-322 |
| ISSN: | 1884-4006 0389-4290 |
| DOI: | 10.2492/jsir1981.14.313 |
| Popis: | To investigate the role of granulocytes in arthritis, extracorporporeal granulocytapherersis (G-1) was performed using the column containing cellulose acetate beads in rabbits with immune arthritis.After injection of ovalbumin into the knee joints of ovalbumin-sensitized animals to induce joint swelling, markedly increased number of granulocytes in peripheral blood and granulocytes accumulation into the arthritic joint were shown. Approximately 18% of granulocytes in whole blood were removed by G-1. Effect of G-1 on granulocytes was investigated by flow cytometry. G-1 treated granulocytes showed a significant decrease in active oxygen production (p |
| Databáze: | OpenAIRE |
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