HEPATOPROTECTIVE ACTIVITY OF SPERMATOZOID STIMULATOR — KATIAZYN UNDER CONDITIONS OF EXPERIMENTAL PARACETAMOL-INDUCED LIVER PATHOLOGY

Autor:	M. Ya. Kudria, N. V. Melnikivs’ka, N. V. Ustenko, T. O. Pavlenko, O. S. Lalymenko, I. A. Palagina, A. L. Degtyaryova, A. D. Ivashchenko
Rok vydání:	2015
Předmět:	Endocrinology Endocrinology Diabetes and Metabolism Pathology and Forensic Medicine
Zdroj:	Problems of Endocrine Pathology. 54:53-60
ISSN:	2518-1432 2227-4782
Popis:	It was investigated hepatoprotective properties of camphor acid derivative — katiazin under experimental model conditions of paracetamol drug-induced hepatitis. It was proved that katiazin in two doses (10 and 50 mg/kg body weight) stimulates the non-enzymatic antioxidant defense unit, increasing the concentration of the reduced glutathione and sulfhydryl groups. The application of katiazin led to an increase in the prothrombin time, which can be interpreted as a sign of the compound anticoagulant effect. It was found out that the administration of katiazin enhances liver detoxification function, normalizes carbohydrate and lipid metabolism in rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b66027ac66f5c484a851e035e0c57ab2 https://doi.org/10.21856/j-pep.2015.4.07 Zobrazit plný text záznamu