Dopamine and hippocampal synaptic plasticity
| Autor: | Alex Ratushnyak, Anna Proskura, Svetlana Vechkapova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Hippocampal synaptic plasticity
Computer science Dopaminergic Glutamate receptor Hippocampus 020206 networking & telecommunications Long-term potentiation 02 engineering and technology Hippocampal formation Synapse Metabotropic receptor Dopamine receptor Dopamine Synaptic plasticity 0202 electrical engineering electronic engineering information engineering medicine General Earth and Planetary Sciences 020201 artificial intelligence & image processing Neuroscience General Environmental Science medicine.drug |
| Zdroj: | Procedia Computer Science. 169:668-672 |
| ISSN: | 1877-0509 |
| DOI: | 10.1016/j.procs.2020.02.186 |
| Popis: | In addition to its role in learning and memory formation, the hippocampus may act as a novelty detector. Hippocampal synaptic plasticity has been implicated in both spatial memory formation as well as novelty acquisition. In addition, the ventral tegmental area-hippocampal loop has been proposed to control the entry of information into long-term memory, whereas the dopaminergic system is be-lieved to play an important role in information acquisition and synaptic plasticity. Physiological and behavioral evidence supports that dopamine receptor signaling influences hippocampal function. Hippocampal synaptic plasticity, in the form of long-term potentiation and long-term depression, has been implicated in both spa-tial memory formation as well as novelty acquisition. However, the molecular mechanisms of synaptic plasticity modulation by dopamine in the hippocampus remain poorly understood. The aim of this study was to achieve a better under-standing of the functional association between glutamate and dopamine receptors on synapses of hippocampal CA1 field. The functional association ionotropic and metabotropic receptors facilitate synaptic plasticity processes in hippocampus. The dopaminergic system gates long-term changes in synaptic strength and these changes are a critical factor in the acquisition of novel information. |
| Databáze: | OpenAIRE |
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