Additions of anionic nucleophiles to carbonyl compounds: Cation and e-lectrophile nature influence on ionic association vs carbonyl complexation control

Autor:	M.-C. Roux-Schmitt, Jacqueline Seyden-Penne, André Loupy
Rok vydání:	1981
Předmět:	Benzaldehyde chemistry.chemical_compound Nucleophile Chemistry Organic Chemistry Drug Discovery Ionic bonding Organic chemistry Biochemistry Medicinal chemistry
Zdroj:	Tetrahedron Letters. 22:1685-1688
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(01)90411-3
Popis:	the reaction of benzaldehyde mth LiCH2CN in THF is controlled by carbonyl complexation while uith KCH2CN the reaction is controlled by ionic association. In the reaction of m.Cl.C6H4CHCN−Li+ with substituted benzaldehydes carbonyl complexation prevails with p.CH3OC6H4CHO while ionic association dominates uith PhCHO and p.CNC6H4CHO.
Databáze:	OpenAIRE
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