Synthesis and stability of sulfur-35 labelled 4-ethylbicyclothiophosphate

Autor:	T. P. Trofimova, S. E. Tkachenko, V. M. Fedoseev
Rok vydání:	1999
Předmět:	chemistry.chemical_compound Thiourea Chemistry Organic Chemistry Radioligand Organic chemistry Isotopes of sulfur Thiophosphate
Zdroj:	Chemistry of Heterocyclic Compounds. 35:973-977
ISSN:	1573-8353 0009-3122
Popis:	Different synthetic routes to the preparation of 4-ethyl-2,6,7-trioxa-1-phosphabicyclo[2,2,2]octane-1-thioxide labelled with sulfur-35 have been investigated since it is of considerable interest as radioligand for neurochemistry. The thiophosphate was successfully synthesized by sulfuration of the corresponding bicyclophosphite by elemental sulfur-35, however the radiochemical purity of the material obtained in this way proves to be low. Convenient methods for synthesis of the thioxide from [35S] thiourea, based on the results of the autoradiolysis of the starting [35S] thiourea, has been discovered giving rise to thioxide with high radiochemical purity. The autoradiolytic stability of the labelled thiophosphate has been studied.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b6475d569fc14d79fa909a345ff03bdb https://doi.org/10.1007/bf02252166 Zobrazit plný text záznamu Full text from SpringerLink