Raman Spectroscopy in Skin Research and Dermal Drug Delivery
| Autor: | Nathalie Jung, Branko Vukosavljevic, Maike Windbergs |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Materials science
integumentary system media_common.quotation_subject 010401 analytical chemistry Raman imaging Nanotechnology 02 engineering and technology Cancer detection 021001 nanoscience & nanotechnology 01 natural sciences Cosmetics 0104 chemical sciences symbols.namesake Skin tissue Drug delivery symbols High spatial resolution Research studies 0210 nano-technology Raman spectroscopy media_common |
| Zdroj: | Confocal Raman Microscopy ISBN: 9783319753782 |
| DOI: | 10.1007/978-3-319-75380-5_17 |
| Popis: | Raman spectroscopy represents an upcoming analytical technique in the field of skin research and dermal drug delivery. In the last few decades, significant progress in optical equipment like lasers and detectors as well as in microscopy and software development paved the way for chemically selective three-dimensional Raman imaging with high spatial resolution. Potential applications range from analysis of physiological and pathophysiological skin conditions (e.g. non-destructive cancer detection in clinics) up to surgery guidance. In the field of drug delivery and cosmetics , Raman microscopy is successfully applied for investigating interactions with skin as well as for elucidation of drug penetration kinetics within the different skin tissue layers, thus strongly supporting rational development and improving product safety of novel skin therapeutics. This chapter provides a brief introduction about skin anatomy and dermal drug delivery systems, as well as state-of-the-art analytics in skin research. Furthermore, the potential of Raman spectroscopy for application in skin research, particularly its advantages and limitations in the field, is comprehensively elaborated. Subsequently, an overview about skin research studies applying Raman spectroscopy is given comprising various in vitro as well as in vivo implementations. Finally, employment of Raman spectroscopy for advanced diagnosis and surgery guidance are discussed and a future perspective in the field of skin research is given. |
| Databáze: | OpenAIRE |
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