Novaxenicins A–D and xeniolides I–K, seven new diterpenes from the soft coral Xenia novaebrittanniae

Autor:	Yoel Kashman, Amira Rudi, Israel Goldberg, Ashgan Bishara, Yehuda Benayahu
Rok vydání:	2006
Předmět:	Chemistry Stereochemistry Coral Organic Chemistry Drug Discovery Xenia Biochemistry Two-dimensional nuclear magnetic resonance spectroscopy Heteronuclear single quantum coherence spectroscopy
Zdroj:	Tetrahedron. 62:12092-12097
ISSN:	0040-4020
DOI:	10.1016/j.tet.2006.09.050
Popis:	Seven new diterpenes, novaxenicins A–D (1–4) and xeniolides I–K (5–7), have been isolated from the Kenyan soft coral Xenia novaebrittanniae. The structures and relative stereochemistry of the compounds were elucidated by interpretation of MS, COSY, HSQC, HMBC, and NOESY experiments. The structure of novaxenicin A (1) was secured by X-ray diffraction analysis. Compound 5 possesses anti-bacterial activity at a concentration of 1.25 μg/ml and compound 2 induces apoptosis in transformed mammalian cells at a concentration of 1.25 μg/ml.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b63f2b049cb8ade75910b8845d51e7ee https://doi.org/10.1016/j.tet.2006.09.050 Zobrazit plný text záznamu Full Text from ScienceDirect