Reduction of Cerebral and Corpus Callosum Volumes in Childhood-Onset Systemic Lupus Erythematosus: A Volumetric Magnetic Resonance Imaging Analysis

Autor: Simone Appenzeller, Bruna Siqueira Bellini, Weslley Geraldo Ferreira, Leticia Rittner, Fernando Cendes, Aline Tamires Lapa, Nailú Angélica Sinicato, Mariana Postal, Paula Teixeira Fernandes, Roberto Marini
Rok vydání: 2016
Předmět:
Zdroj: Arthritis & Rheumatology. 68:2193-2199
ISSN: 2326-5191
DOI: 10.1002/art.39680
Popis: Objective There have been few studies in which the prevalence of cerebral atrophy in childhood-onset systemic lupus erythematosus (SLE) was evaluated using magnetic resonance imaging (MRI) volumetric measurements. This study was undertaken to determine the prevalence of cerebral and corpus callosum atrophy in childhood-onset SLE and to determine the possible relationships between atrophy and clinical, laboratory, and treatment features of the disease. Methods We included 76 patients with childhood-onset SLE (69 female and 7 male; median age 16 years) and 66 age- and sex-matched healthy controls. Neurologic manifestations were analyzed according to the American College of Rheumatology (ACR) criteria. These SLE patients were further assessed for clinical and laboratory manifestations of SLE, disease activity (using the SLE Disease Activity Index), damage (using the Systemic Lupus International Collaborating Clinics/ACR Damage Index), and current and cumulative drug exposures. Scans were performed with a Philips 3.0T MRI scanner using a standardized protocol. Results Childhood-onset SLE patients had significantly smaller cerebral and corpus callosum volumes than controls (median cerebral volume 1,067.9 cm3 versus 1,172.7 cm3 and median corpus callosum volume 11.6 cm3 versus 13.7 cm3; P
Databáze: OpenAIRE
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