Inflamación y adecuación de la hemodiálisis: ¿están los niveles de proteína C reactiva influidos por la dosis de diálisis recibida?
| Autor: | Francisco Valga, Nicanor Vega-Díaz, Tania Monzón, José Carlos Rodríguez-Pérez, Sergio Ruiz-Santana |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Dialysis adequacy biology medicine.diagnostic_test business.industry medicine.medical_treatment C-reactive protein Serum albumin medicine.disease Logistic regression Comorbidity Gastroenterology Nephrology Internal medicine medicine biology.protein Serum iron Hemodialysis business Dialysis |
| Zdroj: | Nefrología. 42:163-170 |
| ISSN: | 0211-6995 |
| DOI: | 10.1016/j.nefro.2021.06.001 |
| Popis: | INTRODUCTION Chronic inflammation and the underlying cardiovascular comorbidity are still current problems in chronic hemodialysis patients. There are few studies comparing the "dialysis dose" (Kt/V) with the degree of inflammation in the patient. Our main objective was to determine whether there is a relationship between serum C-reactive protein (CRP) levels and the Kt/V using ionic dialysance. METHODS Multicenter cross-sectional study. A total of 536 prevalent chronic hemodialysis patients were included. CRP levels, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio were collected. Kt was obtained by ionic dialysance and urea distribution volume was calculated from the Watson's formula. The sample was divided into 2 groups, taking the median CRP as the cut-off point. Dialysis adequacy obtained in each group was compared. Finally, a logistic regression model was carried out to determine the variables with the greatest influence. RESULTS Median CRP was 4.10mg/L (q25-q75: 1.67-10) and mean Kt/V was 1.48±0.308. Kt/V was lower in the patients included in the high inflammation group (P=.01). In the multivariate logistic regression, the "high" levels of CRP were directly correlated with the Log neutrophil-lymphocyte ratio (P |
| Databáze: | OpenAIRE |
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