Effect of Antiorthostatic Hypokinesia on the Pharmacokinetics and Bioavailability of Propranolol

Autor:	S. N. Kondratenko, I. V. Kovachevich, L. G. Repenkova
Rok vydání:	2018
Předmět:	Pharmacology medicine.medical_specialty 010405 organic chemistry Chemistry Pharmacology toxicology Propranolol 01 natural sciences 0104 chemical sciences Bioavailability Absorption rate 010404 medicinal & biomolecular chemistry Endocrinology Pharmacokinetics Hypokinesia Internal medicine Drug Discovery Healthy volunteers medicine medicine.symptom medicine.drug
Zdroj:	Pharmaceutical Chemistry Journal. 52:491-494
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-018-1845-y
Popis:	The pharmacokinetics of propranolol were studied in healthy volunteers after a single peroral administration at a dose of 80 mg under normal conditions, on the second day of antiorthostatic hypokinesia, and on the first day after termination of the hypokinesia. The maximum propranolol concentration (–6 ∆%), area under the pharmacokinetic curve (–13 ∆%), elimination half-life (–15 ∆%), mean residence time in the body (–17 ∆%), and distribution volume (–8 ∆%) tended to decrease with antiorthostatic hypokinesia whereas the total clearance (+13 ∆%), ratio of maximum concentrations (125 ± 23%), and relative absorption rate of the drug (158 ± 48%) increased.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b62b51d9120308b7fe2e7ad36402e471 https://doi.org/10.1007/s11094-018-1845-y Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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