Abstract 2437: Novel metabolic adaptations support proliferation of African American prostate cancer cells under hypoxia
| Autor: | Kiran Kumar Solingapuram Sai, Gagan Deep, Anthony J.A. Molina, Gargi Mahapatra, Taylor C. Peak, Gati K. Panigrahi, Sierra L. Patterson, Steven Kridel, Prakash Priyadarshi Praharaj, Hakeem Oufkir |
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| Rok vydání: | 2018 |
| Předmět: |
Oncology
African american Cancer Research medicine.medical_specialty business.industry Metabolic adaptation Hypoxia (medical) medicine.disease Treatment failure chemistry.chemical_compound Prostate cancer chemistry Internal medicine LNCaP medicine medicine.symptom Growth inhibition business Prostate carcinogenesis |
| Zdroj: | Cancer Research. 78:2437-2437 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/1538-7445.am2018-2437 |
| Popis: | Hypoxia in prostate cancer (PCa) selects for aggressive clones and causes treatment failure, metastatic progression and mortality. Despite the key role of hypoxia in prostate carcinogenesis, little is known about the specific effect of hypoxia in African Americans, a race that faces a serious PCa-related health disparity with the highest incidence and mortality rate. We hypothesize that metabolic adaptation to hypoxia is one mechanism that contributes to PCa aggressiveness in African Americans. Therefore, in the present work we focused on the metabolic adaptations, both in vitro and in vivo, contributing to proliferation of African American PCa cells under hypoxic conditions. PCa cells from men of African American ancestry (E006AA-hT, MDA PCa 2b, WFCB17 and 22Rv1) showed proliferation and significantly higher clonogenicity under hypoxia (1% O2) compared to normoxia. In contrast, Caucasian PCa cells (LNCaP and PC3) showed significant growth inhibition under similar hypoxic condition. The proliferation under hypoxia in African American PCa cells was associated with higher beta-oxidation of lipids as measured by malate response in Oroboros Oxygraph system. In addition, [18F]-fluoro-4-thia-oleate ([18F]-FTO) uptake in African American PCa cells under hypoxia was more than 2-fold higher (p Citation Format: Gati Panigrahi, Prakash Praharaj, Kiran Sai, Gargi Mahapatra, Taylor Peak, Sierra Patterson, Hakeem Oufkir, Anthony Molina, Steven Kridel, Gagan Deep. Novel metabolic adaptations support proliferation of African American prostate cancer cells under hypoxia [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2437. |
| Databáze: | OpenAIRE |
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