| Autor: |
Matilde Jiménez-Coello, Salud Pérez-Gutiérrez, Eugenia Guzman-Marin, Glendy Polanco-Hernández, Karla Y. Acosta-Viana |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
African Journal of Traditional, Complementary and Alternative Medicines. 8 |
| ISSN: |
0189-6016 |
| Popis: |
Antitrypanosomal activity of chloroform extract of Senna villosa leaves was evaluated in the sub acute phase of mice infected with Trypanosoma cruzi. Oral doses of 3.3, 6.6 and 13.2 µg/g were tested during 15 days on infected mice BALB/c, beginning treatment 40 days after infection to evaluate specifically the antitrypanosomal activity over the amastigote form of the parasite. Two different amount of parasites (100 and 500) were inoculated to 25 mice for each doses tested. At the end of the assay the animals were sacrificed and cardiac and skeletal tissue sections were stained with hematoxylin-eosin (HE) for identification and quantification of amastigote nest. In mice infected with 100 parasites, a significant reduction in the number of amastigote nest was observed in cardiac tissue of treated animals at all doses evaluated (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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