Andrographolide protects against isoproterenol-induced myocardial infarction in rats through inhibition of L-type Ca2+ and increase of cardiac transient outward K+ currents
| Autor: | Jader S. Cruz, Matheus V. L. Moreira, Diego Santos Souza, O. T. Adedosu, Marco Tulio Gomes Campos, Marília Martins Melo, Paula Rhana, Dayane L. Naves de Souza, José Evaldo Rodrigues de Menezes-Filho, Danilo Roman-Campos, Tatiane de Oliveira Barreto, Seyi Elijah Elasoru |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pharmacology Myocardial ischemia Isoproterenol Hydrochloride business.industry medicine.medical_treatment Andrographolide Irreversible injury medicine.disease K currents 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Heart failure cardiovascular system medicine Myocardial infarction business Saline 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Pharmacology. 906:174194 |
| ISSN: | 0014-2999 |
| Popis: | Myocardial infarction (MI) is the irreversible injury of the myocardium caused by prolonged myocardial ischemia and is a major cause of heart failure and eventual death among ischemic patients. The present study assessed the protective potentials of andrographolide against isoproterenol-induced myocardial infarction in rats. Animals were randomly divided into four groups: Control (Ctr) group received 0.9% saline solution once daily for 21 days, Isoproterenol (Iso) group received 0.9% saline solution once daily for 19 days followed by 80 mg/kg/day of isoproterenol hydrochloride solution on day 20 and 21, Andrographolide (Andro) group received 20 mg/kg/day of andrographolide for 21 days, and Andrographolide plus Isoproterenol (Andro + Iso) group received 20 mg/kg/day of andrographolide for 21 days with co-administration of 80 mg/kg/day of isoproterenol hydrochloride solution on day 20 and 21. After all treatments, cardiac-specific parameters that define cardiac health and early subacute MI were measured in all groups using both biophysical and pharmacological assay methods. Isoproterenol administration significantly (P |
| Databáze: | OpenAIRE |
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