Antimicrobial tunicamycin derivatives from the deep sea-derivedStreptomyces xinghaiensisSCSIO S15077
| Autor: | Jianhua Ju, Hongbo Huang, Pachaiyappan Saravana Kumar, Chun Gui, Mingwei Shao, Shanwen Zhang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
biology
010405 organic chemistry Organic Chemistry Streptomyces xinghaiensis Plant Science Tunicamycin biology.organism_classification Antimicrobial 01 natural sciences Biochemistry Corpus albicans 0104 chemical sciences Analytical Chemistry Microbiology carbohydrates (lipids) 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Bacillus thuringiensis heterocyclic compounds Antibacterial activity Candida albicans Bacteria |
| Zdroj: | Natural Product Research. 34:1499-1504 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2018.1493736 |
| Popis: | Tunicamycin E (1), featuring a methyl substitution at C-10', was isolated from marine-derived Streptomyces xinghaiensis SCSIO S15077 originated from the South China Sea sediment together with six known compounds, tunicamycin B (2), tunicamycin X (3), tunicamycin A (4), streptovirudin D2 (5), tunicamycin C (6), and tunicamycin C3 (7). The structure of compound 1 was elucidated by detailed spectroscopic data analyses. All the compounds exhibited strong to moderate antibacterial activity against Gram-positive bacteria Bacillus thuringiensis BT01 and B. thuringiensis W102 with MIC values ranging from 0.008 to 2 μg/mL. Moreover, compounds 1-7 exhibited moderate antifungal activity against Candida albicans ATCC 96901 and C. albicans CMCC (F) 98001 with MIC values ranging from 2 to 32 μg/mL. This is the first report that tunicamycins exhibit antimicrobial activities against B. thuringiensis, C. albicans CMCC (F) 98001 and a fluconazole resistant strain C. albicans ATCC 96901. |
| Databáze: | OpenAIRE |
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