Preliminary Report of a Genetic Basis for Cognitive Decline After Cardiac Operations 11The members of the Neurologic Outcome Research Group of the Duke Heart Center are listed in Appendix A
| Autor: | James A. Blumenthal, Ann M. Saunders, Barbara E. Tardiff, Warren J. Strittmatter, Joseph G. Reves, Narda D. Croughwell, A. D. Roses, Robert D. Davis, Mark F. Newman, William D. White |
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| Rok vydání: | 1997 |
| Předmět: |
Pulmonary and Respiratory Medicine
Apolipoprotein E medicine.medical_specialty Apolipoprotein B biology business.industry Cognition Logistic regression medicine.disease law.invention Surgery Cognitive test law Internal medicine biology.protein Cardiopulmonary bypass medicine Cardiology Cognitive decline Cardiology and Cardiovascular Medicine business Postoperative cognitive dysfunction |
| Zdroj: | The Annals of Thoracic Surgery. 64:715-720 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/s0003-4975(97)00757-1 |
| Popis: | Background . Changes in memory and cognition frequently follow cardiac operations. We hypothesized that patients with the apolipoprotein E-ϵ4 allele are genetically predisposed to cognitive dysfunction after cardiac operations. Methods . The apolipoprotein E-ϵ4 allele was evaluated as a predictor variable for postoperative cognitive dysfunction in 65 patients undergoing cardiac bypass grafting at Duke University Medical Center. The primary outcome measure was performance on a cognitive battery administered preoperatively and at 6 weeks postoperatively. Results . In a multivariable logistic regression analysis including apolipoprotein E-ϵ4, preoperative score, age, and years of education, a significant association was found between apolipoprotein E-ϵ4 and change in cognitive test score in measures of short-term memory at 6 weeks postoperatively. Patients with lower educational levels were more likely to show a decline in cognitive function associated with the apolipoprotein E-ϵ4 allele. Conclusions . This study suggests that apolipoprotein E genotype is related to cognitive dysfunction after cardiopulmonary bypass. Cardiac surgical patients may be susceptible to deterioration after physiologic stress as a result of impaired genetically determined neuronal mechanisms of maintenance and repair. |
| Databáze: | OpenAIRE |
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