| Autor: |
Kamilla Menezes Oliveira, Lucas Magalhães Alcântara, Fernanda Gabriela Teixeira, Samir Andrade Mendonça, Djanilson Barbosa Dos Santos, Lucas Miranda Marques, Maise Mendonça Amorim, Raquel de Souza Gestinari |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Arquivos em Odontologia. 51 |
| ISSN: |
2178-1990 |
| DOI: |
10.7308/aodontol/2015.51.4.01 |
| Popis: |
Aim: This study aimed to analyze the relationship between the polymorphism c.-889 C>T in the IL1A gene and periodontitis in subjects from Vitória da Conquista, Bahia, Brazil. Methods: Two hundred fifty-nine individuals were classified according to periodontitis diagnoses in cases and controls. Genomic DNA was extracted from buccal epithelial cells. Genotyping was performed by PCR-RFLP, followed by agarose gel electrophoresis. Data were analyzed using Chi-square, Fisher’s exact and Hosmer-Lemeshow tests. Results: In the individuals evaluated in this study, periodontitis was significantly associated with a low educational level (p = 0.024) and clinical variables, such as gingival bleeding (p = 0.019) and tooth mobility (p = 0.001). Among patients in the case group, the majority (72.88%) had a generalized form of periodontitis. The genotypic frequencies for IL1A c.–889 C>T between the case and control groups did not significantly differ (χ2 = 1.6983; p = 0.428). Conclusion: This study’s findings indicate the lack of association between periodontitis and the IL1A c -889 C>T gene polymorphism.Uniterms: Peridontitis. Genetic polymorphism. Interleukin-1. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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