A New Class of Antifungal Agents. Synthesis and Antimycotic Activity of DisubstitutedN-Azolylamines

Autor: Chiara Musiu, Giorgio Stefancich, Paolo La Colla, Sabrina Castellano
Rok vydání: 2000
Předmět:
Zdroj: Archiv der Pharmazie. 333:299-304
ISSN: 1521-4184
0365-6233
DOI: 10.1002/1521-4184(20009)333:9<299::aid-ardp299>3.0.co;2-f
Popis: In this study we extended our exploration of the N-azolylamine moiety for its antifungal activity. We prepared a number of N-azolylamino derivatives. The synthetic sequence includes the preparation of aminoazole Schiff bases, and the reduction and the alkylation of the corresponding secondary amines. The title compounds were evaluated in vitro against several pathogenic fungi responsible for human disease. The most potent antimicrobial compound was the N-(biphenyl-4-yl)methyl-N-(2,4-dichlorophenyl) methyl-1H-imidazol-1-ylamine (21), which was found to be active against yeasts and dermatophytes; its potency and selectivity were comparable to those of miconazole.
Databáze: OpenAIRE