A New Class of Antifungal Agents. Synthesis and Antimycotic Activity of DisubstitutedN-Azolylamines
Autor: | Chiara Musiu, Giorgio Stefancich, Paolo La Colla, Sabrina Castellano |
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Rok vydání: | 2000 |
Předmět: | |
Zdroj: | Archiv der Pharmazie. 333:299-304 |
ISSN: | 1521-4184 0365-6233 |
DOI: | 10.1002/1521-4184(20009)333:9<299::aid-ardp299>3.0.co;2-f |
Popis: | In this study we extended our exploration of the N-azolylamine moiety for its antifungal activity. We prepared a number of N-azolylamino derivatives. The synthetic sequence includes the preparation of aminoazole Schiff bases, and the reduction and the alkylation of the corresponding secondary amines. The title compounds were evaluated in vitro against several pathogenic fungi responsible for human disease. The most potent antimicrobial compound was the N-(biphenyl-4-yl)methyl-N-(2,4-dichlorophenyl) methyl-1H-imidazol-1-ylamine (21), which was found to be active against yeasts and dermatophytes; its potency and selectivity were comparable to those of miconazole. |
Databáze: | OpenAIRE |
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