| Autor: |
Toshito Nakagawa, Kazumi Ohkubo, Akira Okazaki, Masaki Ishigai, Yuka Hiramatsu, Yoshihiko Ishitani |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Drug Metabolism and Pharmacokinetics. 10:625-636 |
| ISSN: |
0916-1139 |
| DOI: |
10.2133/dmpk.10.625 |
| Popis: |
The metabolism of 14C labeled Q-35 [(±)-1-cyclopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7 (3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid], a new fluoroquinolone antimicrobial agent, was studied in rats and dogs.1. Two metabolites were identified in the urine and the bile (or the feces) after a sigle oral administration of 14C-Q-35 to rats and dogs: glucuronic acid conjugate of Q-35 as the main metabolite and aminopiperidinyl N-desmethylated derivative (N-desmetyl Q-35) as a minor metabolite.2. Q-35 glucuronide was excreted mainly in the bile or feces. Most of the radioactivity in the urine and the plasma was unchanged Q-35.3. The bioautographic study revealed that the antibacterial activity present in the urine and the bile was related to unchanged Q-35 but not to its metabolites. These results indicate that the transformation of Q-35 hardly occurs and that most of the drug administerd remains unchanged Q-35 in rats and dogs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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