Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver
| Autor: | Daigo Asano, Koichi Nakamura, Yumi Nishiya, Hideyuki Shiozawa, Hideo Takakusa, Takahiro Shibayama, Shin-ichi Inoue, Tsuyoshi Shinozuka, Takakazu Hamada, Chizuko Yahara, Nobuaki Watanabe, Kouichi Yoshinari |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Drug Metabolism and Disposition. 51:67-80 |
| ISSN: | 1521-009X 0090-9556 |
| DOI: | 10.1124/dmd.122.001000 |
| Databáze: | OpenAIRE |
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