Temperature-responsive Hydrogels Synthesized from Photo-Polymerizable Poloxamer Macromers for Topical Skin Moisturizing
| Autor: | Jun Bae Lee, Yea Ram Lee, Yoon Sung Nam, Jin Woong Kim |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Aqueous solution
Chemistry technology industry and agriculture Structural integrity macromolecular substances 02 engineering and technology General Chemistry Poloxamer 010402 general chemistry 021001 nanoscience & nanotechnology complex mixtures 01 natural sciences 0104 chemical sciences Chemical engineering Skin surface Self-healing hydrogels medicine Copolymer Swelling medicine.symptom 0210 nano-technology |
| Zdroj: | Bulletin of the Korean Chemical Society. 37:1331-1336 |
| ISSN: | 1229-5949 |
| DOI: | 10.1002/bkcs.10865 |
| Popis: | Temperature-responsive hydrogels were fabricated by the photo-polymerization of bis-acryloyl poloxamer tri-block copolymers, and their temperature-responsive behavior and physiological effect on skin were investigated. For this, poloxamer macromers were prepared by end-capping both terminal hydroxyl groups of poloxamer tri-block copolymers with acrylates. They were then photo-polymerized to generate polymeric hydrogels with structural integrity that allowed excellent stability against dilution in an aqueous environment. The resulting hydrogels exhibited dramatic reversible swelling behavior upon changes in temperature. A demonstration experiment, in which the hydrogels were applied topically to the skin, showed that they shrank rapidly as a result of the increase in temperature, owing to the contact with the skin surface, highlighting their effectiveness for instantaneously moisturizing the skin. |
| Databáze: | OpenAIRE |
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