Evaluating menopausal women with histories of thrombotic and phlebitic symptoms for HRT
| Autor: | Lisa Barrie Schwartz, Henriette Lackner, Lila E. Nachtigall, Meryl Mark, Stephanie Bialek |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Hypercoagulable states
medicine.medical_specialty genetic structures business.industry medicine.medical_treatment Obstetrics and Gynecology Hormone replacement therapy (menopause) medicine.disease Thrombosis eye diseases Surgery Internal medicine Medicine sense organs Activated protein C resistance business General Nursing |
| Zdroj: | Primary Care Update for OB/GYNS. 4:32-37 |
| ISSN: | 1068-607X |
| DOI: | 10.1016/s1068-607x(96)00055-8 |
| Popis: | We studied the use of a complete hemostatic profile for evaluating postmenopausal (PMP) women with histories of thrombosis or phlebitis who were presenting for hormone replacement therapy (HRT). Eighteen PMP women with histories of thrombotic or phlebitic symptoms who presented to our Menopausal Unit for HRT underwent complete hemostatic profiles, and decisions regarding HRT use were made based on the results and concurrent risk-factor analysis. Nine of 18 women had a hemostatic abnormality: one protein C, six protein S, one activated protein C resistance, and one anticardiolipin (ACA) antibody. None of the patients with protein C or S deficiencies subsequently received HRT. The patient with a positive ACA has used HRT with coumadin, without incident. Five of the nine patients with normal profiles have been treated with HRT without any short-term complications. A complete hemostatic evaluation thus aids in diagnosing underlying hypercoagulable states and may be useful for directing medical decisions regarding HRT for PMP women with histories of thrombosis or phlebitis. |
| Databáze: | OpenAIRE |
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