The prognostic value of immunohistochemical analysis of squamous cell cervical carcinoma for pS2

Autor: J. Murdoch, R. Start, T. Olatinwo, J. H. F. Smith, F. Sharp
Rok vydání: 1996
Předmět:
Zdroj: International Journal of Gynecological Cancer. 6:205-207
ISSN: 1525-1438
1048-891X
DOI: 10.1046/j.1525-1438.1996.06030205.x
Popis: The objective of this study was to examine the value of tumor expression of pS2 in patients with squamous cell carcinoma of the cervix and to correlate these with estrogen receptor (ER) status and prognosis. Tissue sections from 57 cases of histologically confirmed squamous cell carcinoma of the cervix, managed in hospitals in Sheffield between May, 1983 and July, 1986, were analyzed for pS2 expression using a standard immunohistochemical technique. Tissue ER status had been established previously. FIGO staging, histological diagnosis, degree of tumor differentiation and other clinical details relating to menopausal status and outcome after 5 years follow-up were retrospectively collected from the clinical records. Prognosis was correlated with pS2 expression alone and with combined pS2 and ER status. Eighteen (31.6%) of the tumors stained positively for pS2; 42 (73.7%) were ER positive and 13 (22.8%) were concomitantly positive for pS2 and ER. There was no correlation between pS2 and ER (Fisher’s Score=1.35). The clinical staging of the tumors, the degree of differentiation and the menopausal status of the patients also showed no correlation with pS2 expression (P values> 0.05). Neither pS2 status alone nor combined pS2 and ER status accurately predicted prognosis in the study concluding that pS2 expression does not predict prognosis in cervical squamous cell cancer.
Databáze: OpenAIRE
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