An asymmetric approach to the pyrrolizidine ring system via N-acetyl and N-propionyl anion cyclisation processes

Autor:	Anthony Murray, P.John Murray, George R. Proctor
Rok vydání:	1995
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Drug Discovery Pyrrolizidine Ring (chemistry) Biochemistry Ion
Zdroj:	Tetrahedron Letters. 36:291-294
ISSN:	0040-4039
DOI:	10.1016/0040-4039(94)02233-2
Popis:	An efficient route to the pyrrolizidine ring system has been developed. The method, which uses N-acetyl and N-propionyl anion cyclisation reactions as the key steps has provided the natural pyrrolizidines (−)-(1R, 8S)-1-hydroxy-pyrrolizidine (10), (−)-pyrrolizidin-1-ene-3-one (13), (±)-trachelanthamidine (18) together with a range of 2-methyl substituted pyrrolizidine-3-ones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b5e2893da501a33bdf9d5729b0fc0cf8 https://doi.org/10.1016/0040-4039(94)02233-2 Zobrazit plný text záznamu Full Text from ScienceDirect