Tissue Repair and Regeneration

Autor: Astrid Limb, PT Khaw, Maryse Bailly, Julie Daniels, Stelios Georgoulas, Annegret H. Dahlmann, Kamiar Mireskandari, Stephen Brocchini
Rok vydání: 2008
Předmět:
Popis: Publisher Summary Damage and degeneration of tissues in and around the eye frequently leads to visual impairment because of the anatomy and physiology of the eye. Consequently, repair processes play a role in most major blinding eye conditions or the failure of treatment. Cataract is the most important cause of world blindness, and degenerative processes with a repair response play a part in both the formation of cataract and the after cataract in capsule sparing surgery. Lid contraction and corneal scarring result in blindness in trachoma, and conjunctival fibrosis blinds after burns or autoimmune diseases such as cicatricial pemphigoid. Following glaucoma surgery, post-operative sub-conjunctival scarring results in sub-optimal pressure control and disease progression, and similar scarring restricts the predictability of strabismus surgery and contributes to motility problems in thyroid eye disease. Retinal scarring in proliferative vitreoretinopathy, and specifically age related macular degeneration, results in more loss of vision than any other disease in the developed world. Treatments and surgical approaches have been developed to successfully modulate the wound healing response. Anti-cancer agents such as mitomycin C inhibit fibroblast function and survival when applied locally. Steroids applied topically and systemically reduce inflammation and fibrosis. However, both these agents have significant side effects. This chapter reviews the agents used to modulate healing scarring.
Databáze: OpenAIRE
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