The Relationship Between the Dissolution Rate and the Particle Size of Prednimustine: A Disagreement with the Noyes-Whitney Equation

Autor:	T. Lundstedt, N.-O. Lindberg
Rok vydání:	1994
Předmět:	Pharmacology Chemistry Prednimustine Organic Chemistry Pharmaceutical Science Mineralogy Thermodynamics Regression analysis chemistry.chemical_compound Pharmaceutical technology Agglomerate Drug Discovery Crystallite Particle size Dissolution
Zdroj:	Drug Development and Industrial Pharmacy. 20:2547-2550
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049409042658
Popis:	It is widely known from textbooks that the particle size -- or the surface area, inversely related to the particle size -- of a drug influences its dissolution rate; this is the relationship expressed in the so-called Noyes-Whitney equation (1). Studies of prednimustine -- a drug practically insoluble in water, and characterized by wide multimodal size distributions, composed of single crystallites as well as aggregates and agglomerates -- did not indicate any general correlation between particle size and dissolution rate, neither by means of regression analysis (2) nor by way of multivariate data analysis (3). Fair correlations were obtained with a set of small-scale batches, with wide intervals regarding both particle-size and dissolution-rate parameters
Databáze:	OpenAIRE
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