New tetracyclic 1,4-oxazepines constructed via practically simple tandem condensation strategy from readily available synthons

Autor:	Stanislav Kalinin, Alexey V. Smirnov, Mikhail V. Dorogov, Alexander Sapegin, Mikhail Krasavin
Rok vydání:	2014
Předmět:	Tandem Chemistry Computational chemistry Simple (abstract algebra) Nucleophilic aromatic substitution Organic Chemistry Drug Discovery Synthon Condensation Structural isomer Smiles rearrangement Electrophilic aromatic substitution Biochemistry
Zdroj:	Tetrahedron. 70:1077-1083
ISSN:	0040-4020
DOI:	10.1016/j.tet.2013.12.026
Popis:	A streamlined synthetic methodology towards novel tetracyclic 1,4-oxazepines from readily available precursors is described. The compounds, designed as more soluble version of the earlier described, poorly soluble dibenzo[b,f][1,4]oxazepines, were obtained in high yields and as a single regioisomer as a result of three tandem chemical events—nucleophilic aromatic substitution, Smiles rearrangement and denitrocyclization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b5c92446598b82d45ba7af75ce4d3ffb https://doi.org/10.1016/j.tet.2013.12.026 Zobrazit plný text záznamu Full Text from ScienceDirect