Antithrombotic Study and Identification of Metabolites in Leaf Extracts of Chaya [Cnidoscolus aconitifolius (Mill.) I.M. Johnst.]
| Autor: | Maira Rubí Segura-Campos, Juan Pablo Quintal-Martínez, David Muñoz-Rodríguez, Ligia Gabriela Alonzo-Salomón, Irma Guadalupe Quintal-Ortiz |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Nutrition and Dietetics
Traditional medicine medicine.diagnostic_test biology Ethyl acetate Medicine (miscellaneous) biology.organism_classification Terpene chemistry.chemical_compound Nutraceutical chemistry Antithrombotic medicine Platelet aggregation inhibitor Fibrinolytic agent circulatory and respiratory physiology Partial thromboplastin time Cnidoscolus aconitifolius |
| Zdroj: | Journal of Medicinal Food. 24:1304-1312 |
| ISSN: | 1557-7600 1096-620X |
| Popis: | In Mexico, Cnidoscolus aconitifolius (chaya) has been used to treat cardiovascular diseases (CVD). Because CVD are the number one cause of mortality, chaya use has become a health strategy. The aim of this study was to evaluate the antithrombotic activity and identify the metabolites in the most active extract. Aqueous (Aq), ethanolic (EtOH), acetonic (An), ethyl acetate (AcOEt), diethyl ether (Et2O), and hexanic (Hx) extracts were obtained. Platelet aggregation, phospholipase A2, prothrombin time (PT), activated partial thromboplastin time (aPTT), and clot lysis were evaluated. Metabolites were identified by gas chromatography-mass spectrometry (GC-MS). EtOH showed the greatest inhibition of platelet aggregation and phospholipase A2. Ac had the greatest effect on PT and aPTT. AcOEt had the greatest effect on clot lysis. EtOH, with the highest potential, was analyzed by GC-MS; fatty acids and triterpenes were identified. Thus, EtOH showed greater antiplatelet activity and other extracts showed moderate activity. This is a preliminary antithrombotic study. Future research will allow the development of nutraceuticals or functional ingredients for the prevention and treatment of thrombosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|