Silver-Mediated Intramolecular Friedel–Crafts-Type Cyclizations of 2-Benzyloxy-3-bromoindolines: Synthesis of Isochromeno[3,4-b] indolines and 3-Arylindoles

Autor:	Takahide Nishi, Yutaro Tomisaka, Koji Yamada, Takumi Abe, Toshiki Yamashiro, Haruka Yoshida
Rok vydání:	2019
Předmět:	010405 organic chemistry Chemistry Intramolecular force Organic Chemistry 010402 general chemistry 01 natural sciences Friedel–Crafts reaction Medicinal chemistry 0104 chemical sciences
Zdroj:	Synlett. 30:2247-2252
ISSN:	1437-2096 0936-5214
Popis:	We disclose a silver-mediated intramolecular Friedel–Crafts-type cyclization of 2-benzyloxy-3-bromoindolines to afford an untapped family of isochromeno[3,4-b]indolines and 3-arylindoles, in which deformylative arylation of 2-(4-methoxybenzyloxy)-3-bromoindolines is reported for the first time. The isochromeno[3,4-b]indolines can be readily transformed into other heterocyclic moieties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b5be46e6bfaf081a58401e2aa6df8673 https://doi.org/10.1055/s-0039-1690734 Zobrazit plný text záznamu