| Autor: |
Robert Pickard, Ased Ali, C.L. Townes, Craig N. Robson, Judith Hall, SC Williamson, Rakesh Heer, Deepali Pal, Naomi Gross |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
The Prostate. 73:1529-1537 |
| ISSN: |
0270-4137 |
| DOI: |
10.1002/pros.22700 |
| Popis: |
BACKGROUND This study investigated whether the increase in serum prostate specific antigen (PSA) typically seen during male urinary tract infection (UTI) is incidental or reflects an innate defence mechanism of the prostate. The protective roles of the whey-acid-motif-4-disulphide core (WFDC) proteins, secretory leukoproteinase inhibitor (SLPI) and WFDC2, in the prostate were also examined. METHODS UTI recurrence was assessed retrospectively in men following initial UTI by patient interview. PSA, SLPI, and WFDC2 gene expression were assessed using biopsy samples. LNCaP and DU145 in vitro prostate cell models were utilized to assess the effects of an Escherichia coli challenge on PSA and WFDC gene expression, and bacterial invasion of the prostate epithelium. The effects of PSA on WFDC antimicrobial properties were studied using recombinant peptides and time-kill assays. RESULTS Men presenting with PSA >4 ng/ml at initial UTI were less likely to have recurrent (r) UTI than those with PSA |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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