PS-300 Choriamnionitis And Crp As Markers For Short And Long Term Outcomes In Premature Infants

Autor:	Ricardo Segurado, Paul Downey, Eleanor J. Molloy, Eoghan E. Mooney, Sarah Alnafisee, Emer Ryan, Doireann Eves, P Jayadev Menon
Rok vydání:	2014
Předmět:	medicine.medical_specialty Pregnancy Pediatrics Resuscitation Fetus Obstetrics business.industry Birth weight Gestational age medicine.disease Chorioamnionitis Early onset sepsis Pediatrics Perinatology and Child Health medicine Long term outcomes business
Zdroj:	Archives of Disease in Childhood. 99:A220.1-A220
ISSN:	1468-2044 0003-9888
DOI:	10.1136/archdischild-2014-307384.599
Popis:	Background Early infant CRP levels in the setting of Chorioamnionitis (CA) have not been fully defined as a predictor of cognitive, behavioural, and neuro-developmental outcomes among extremely preterm neonates. Methods 499 preterm neonates had Placental pathology, CRP level and Vermont Oxford outcomes recorded. Death and developmental outcomes at 2 yrs were examined for 247 preterm infants Results 499 preterm infants were included with mean birth weight of 1074 +/- 273 g and gestational age of 28.5 +/-2.7 weeks. Infants with CA (N = 127) had lower GA and birth weight and higher rates of early onset sepsis. The Fetal inflammatory response was associated with: Apgar Infants with Day 1 CRP >10 mg/L needed significantly more resuscitation in the Delivery room (DR) including adrenaline and cardiac compressions. They were significantly more at risk of RDS, ROP, grade III/IV IVH. Conclusion There is a correlation between both initial CRP and histological CA with adverse short term outcomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b5b5aa43124d41be0aacfcb092c87905 https://doi.org/10.1136/archdischild-2014-307384.599 Zobrazit plný text záznamu