Breast conserving surgery (BCS) with adjuvant radiation therapy showed improved prognosis compared with mastectomy for early staged triple negative breast cancer patients
| Autor: | Song Jiao Zhao, Feng Wei, Yi di Sun, Shuo Er Wang, Gong Yang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment 02 engineering and technology Breast cancer Internal medicine 0502 economics and business 0202 electrical engineering electronic engineering information engineering medicine Breast-conserving surgery Survival analysis Triple-negative breast cancer integumentary system Proportional hazards model business.industry Applied Mathematics 05 social sciences General Medicine medicine.disease Radiation therapy Computational Mathematics Modeling and Simulation Cohort 020201 artificial intelligence & image processing General Agricultural and Biological Sciences business 050203 business & management Mastectomy |
| Zdroj: | Mathematical Biosciences and Engineering. 17:92-104 |
| ISSN: | 1551-0018 |
| Popis: | Background: Triple-negative breast cancer (TNBC) is a subtype of breast cancer with stronger invasive capacity. For the operation strategies of early staged (stage I and stage II) TNBC patients, BCS plus radiotherapy (BCS+RT), mastectomy only (MRM only) or MRM plus radiotherapy (MRM+RT) is feasible, but no clear conclusion has been made on the choice of these treatments. Methods: The early staged TNBC patients (stage I and stage II) from the Surveillance, Epidemiology and End Results (SEER) program database between 1973 and 2014 were included in the study. Survival curves, univariate and multivariate cox proportional hazards models and propensity score weighting were applied to evaluate the prognostic impact among BCS+RT, MRM only and MRM+RT for patients. Results: Both overall and cancer-specific survival analysis showed that BCS+RT had better prognostic effect than MRM and MRM+RT in the cohort of early-staged triple-negative breast cancer patients (overall survival, P Conclusion: BCS+RT demonstrated better prognosis than MRM only and MRM+RT treatments for early-staged TNBC patients. |
| Databáze: | OpenAIRE |
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