Synthesis of 2H-benzo[2,3-g]pyridazino-[4,5-d,e]quinolin-3-one derivatives

Autor:	L. Chaker, Félix Pautet, Houda Fillion
Rok vydání:	1997
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Nucleophile chemistry Carboxylic acid Hydrazine Structural isomer General Chemistry Medicinal chemistry
Zdroj:	Monatshefte f�r Chemie Chemical Monthly. 128:681-685
ISSN:	1434-4475 0026-9247
DOI:	10.1007/bf00807599
Popis:	Condensation-cyclization of hydrazine with 4-methoxycarbonylbenzo[g]quinolinequinone or its corresponding carboxylic acid afforded 7-hydrazino-2H-benzo[2,3-g]pyridazino[4,5-d,e]-quinolin-3-one. Starting with the 9-hydroxy derivative, a similar double condensation of the nucleophile was observed, whereas its 6-hydroxylated regioisomer gave 2H-benzo[2,3-g]pyridazino-[4,5-d,e]quinolin-3,7-dione.
Databáze:	OpenAIRE
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